Exocrine Pancreatic Insufficiency (EPI) is a condition in which your body doesn’t provide enough pancreatic enzymes to properly break down food. People with EPI are unable to properly digest the nutrients in food such as fats, proteins, and carbohydrates, leading to maldigestion. Once diagnosed, EPI is a manageable condition when treated with pancreatic enzyme replacement therapy (PERT) as part of an EPI management plan.